Manuscripts

The Rise of Psilocybin Use in the United States: A Multisource Observational Study. JC.Black, K.M. Rockhill, M.S. Ladka, K.B. Sumbundu, H.A. Olsen, J.S. Jewell, J Hunt (SAMHSA), R. Cameron Wolf (SAMHSA), K Nerurkar (SAMHSA), R.C. Dart, A.Monte

A Cross-Sectional Study of Tampering in Xtampza ER, an Abuse-Deterrent Formulation of an Extended-Release Opioid, in a Treatment Center Population. Clin Drug Investig (2023). Jewell, J., Black, J., Ellis, M., Olsen, H., Iwanicki, J., Dart, R.

Trends in characteristics of prescription opioid-related poisonings among older adults in the United States, 2015-2021. Journal of Addiction Medicine, 2023; in press. Han BH, Jewell JS, Ding B, Wu NC, Cottler LB, Palamar JJ.

Differing Behaviors Around Adult Nonmedical Use of Prescription Stimulants and Opioids: Latent Class Analysis. J Med Internet Res 2023 Sept 20;25:e46742 Rockhill, K.M., Olson, R., Dart, R.C., Iwanicki, J.L., Black, J.C.

Comparing Substance Use Consequences between Serotonergic Psychedelics, MDMA, and other Drugs of Abuse Among United States Adults with History of Psychiatric Illness. Int J Ment Health Addiction 2023 Sept 26. Black, J.C., Schow, N., Burkett, H.L. et al.

Initiation Patterns and Transitions Among Adults Using Stimulant Drugs: Latent Transition Analysis J Med Internet Res 2023 May 10; 25:e46747. Black, J.C., Burkett, H.L., Rockhill, K.M., Olson, R., Dart, R.C., Iwanicki, J.

Trends in Characteristics of Fentanyl-Related Poisonings in the United States, 2015-2021. American Journal on Drug and Alcohol Abuse.Palamar JJ, Cottler LB, Goldberger BA, Severtson SG, Grundy DJ, Iwanicki JL, Ciccarone D.

Changes in the Street Prices of Prescription Opioids During the COVID-19 Pandemic. Mutter R, Black J, Iwanicki J.

Clustering patterns in polysubstance mortality in the United States in 2017: a multiple correspondence analysis of death certificate data. Black JC, Rockhill KM, Dart RC, Iwanicki JL. Ann Epidemiol

Nonmedical use of gabapentin and opioid agonist medications in treatment-seeking individuals with opioid use disorder. Drug and Alcohol Dependence

Associations of transactional sex and sexually transmitted infections among treatment-seeking individuals with opioid use disorder. Ellis MS, Kasper ZA, Takenaka B, Buttram ME, Shacham E. Am J Prev Med

Changes in hydrocodone misuse exposures reported to US poison centers following rescheduling in 2014. Fischer LJ, Severtson SG, Gurrola MC, Iwanicki JL, Green JL, Dart RC.

Characteristics of poisonings involving ketamine in the United States, 2019–2021. J Psychopharmacol. Palamar JJ, Fitzgerald ND, Grundy DJ, Black JC, Jewell JS, Cottler LB.

Evaluation of cannabis use among US adults during the COVID-19 pandemic within different legal frameworks. JAMA Netw Open. Black JC, Amioka E, Iwanicki JL, Dart RC, Monte AA.

Association of medical stimulants with mortality in the US from 2010 to 2017
Black JC, Bau GE, Iwanicki JL, Dart RC
JAMA Intern Med.

Drug product dispensing and estimates of use in a general population survey as a signal detection problem
Black JC, Forber A, Severtson SG, Rockhill K, May KP, Amioka E, Schwarz J, Iwanicki JL, Dart RC
Pharmacoepidemioloyg & Drug Safety

Web-Based Discussion and Illicit Street Sales of Tapentadol and Oxycodone in Australia: Epidemiological Surveillance Study
Black JC, Margolin ZR, Bau GE, Olson R, Iwanicki JL, Dart RC
JMIR Public Health Surveill

Increasing rates of buprenorphine diversion in the United States, 2002 to 2019 Buttram ME, Kurtz SP, Margolin ZR, Severtson SG. Pharmacoepidemiology & Drug Safety

Measuring prescription opioid misuse and its consequences
Dart RC, Iwanicki JL, Black JC, Olsen HA, Severtson SG
British Pharmacological Society

Shifting Pathways of Stimulant Use Among Individuals With Opioid Use Disorder: A Retrospective Analysis of the Last Thirty Years
Ellis MS, Kasper ZA, Scroggins S
Front. Psychiatry

Non-medical Use of Prescription Gabapentinoids (Gabapentin and Pregabalin) in Five European Countries
Fonseca F, Lenahan W, Dart RC, et al.
Front Psychiatry

Non-medical use of benzodiazepines and GABA analogues in Europe
Hockenhull J, Amioka E, Black JC, Forber A, Haynes CM, Wood DM, Dart RC, Dargan PI
Br J Clin Pharmacol

Nonmedical use of benzodiazepines and Z-drugs in the UK
Hockenhull J, Black JC, Haynes CM, Rockhill K, Dargan PI, Dart RC, Wood DM
BJCP

Prevalence and description of kratom (Mitragyna speciosa) use in the United States: A cross‐sectional study
Schimmel J, Amioka E, Rockhill K, Haynes CM, Black JC, Dart RC, Iwanicki JL
SSA

Early-readmission after Agonist Opioid Treatment in five European countries. A drug addiction health policy challenge?

Tramadol non-medical use in four European countries: A comparative analysis
Iwanicki JL, Schwarz J, May KP, Black JC, Dart RC.
Drug Alcohol Depend. 2020 Oct 20

Postmarketing Analysis of Misuse, Abuse, and Diversion of Xtampza ER
Severtson SG, Kreider SED, Amioka EC, Margolin ZR, Iwanicki JI, Dart RC
Pain Med. 2020

Online Conversation Monitoring to Understand the Opioid Epidemic: Epidemiological Surveillance Study
Black JC, Margolin ZR, Olson RA, Dart RC
JMIR Public Health Surveillance

Misuse of prescription medicines is as prevalent as the use of recreational drugs and novel psychoactive substances in Singapore
Chan WL, Dargan PI, Haynes CM, Green JL, Black JC, Dart RC, Wood DM
Singapore Med J

The impact of the prescription opioid epidemic on young children: Trends and mortality
Wang GS, Olsen HA, Severtson SG, Green JL, Dart RC
Drug Alcohol Depend

Polysubstance use: A broader understanding of substance use during the opioid crisis
Cicero TJ, Ellis MS, Kasper ZA
Am J Public Health

Non-medical use of loperamide in the UK and USA
Webb NE, Wood DM, Black JC, Amioka E, Dart RC, Dargan PI
QJM

The impact of opioid use disorder on levels of educational attainment: Perceived benefits and consequences
Ellis MS, Kasper ZA, Cicero TJ
Drug Alcohol Depend

Changes in mortality involving extended-release and long-acting opioids after implementation of a Risk Evaluation and Mitigation Strategy
Black JC, Bau GE, Rosen T, Cepeda MS, Wedin GP, Green JL, Dart RC
Pain Med

An online survey for pharmacoepidemiological investigation (Survey of Non-Medical Use of Prescription Drugs Program): validation study
Black JC, Rockhill K, Forber A, Amioka E, May KP, Haynes CM, Dasgupta N, Dart RC
J Med Internet Res

Real-world misuse, abuse, and dependence of abuse-deterrent versus non-abuse-deterrent extended-release morphine in Medicaid noncancer patients
Cicero TJ et al.
Postgrad Med J

Commentary on Mintz et al. (2019): Unintended or intended? Coming to grips with the opioid crisis
Dart RC
Addiction

Causal inference for evaluating prescription opioid abuse using trend‐in‐trend design
Dasgupta N, Schwarz J, Hennessy S, Ertefaie A, Dart RC
Pharmacoepidemiol Drug Saf

Understanding multi‐pill ingestion of prescription opioids: Prevalence, characteristics, and motivation
Ellis MS, Cicero TJ, Dart RC, Green JL
Pharmacoepidemiol Drug Saf

Nonmedical use of alprazolam in the UK: Results from a nationally representative survey
Hockenhull J, Amioka E, Black JC, Haynes CM, Dargan PI, Dart RC, Wood DM
Br J Clin Pharmacol

The diversion of nonscheduled psychoactive prescription medications in the United States, 2002 to 2017
Kurtz SP, Buttram ME, Margolin ZR, Wogenstahl K
Pharmacoepidemiol Drug Saf.

Scoring the best deal: Quantity discounts and street price variation of diverted oxycodone and oxymorphone
Lebin JA, Murphy DL, Severtson SG, Bau GE, Dasgupta N, Dart RC
Pharmacoepidemiol Drug Saf

Brief report: Characterization of marijuana use in us college students by state marijuana legalization status as reported to an online survey
Wang GS, Haynes C, Besharat A, Lait ML, Green JL, Dart RC, Roosevelt G
Am J Addict

Understanding abuse of buprenorphine/naloxone film versus tablet products using data from ASI-MV® substance use disorder treatment centers and RADARS System Poison Centers
Butler et al.
J Subst Abuse Treat

Trends in intentional abuse or misuse of benzodiazepines and opioid analgesics and the associated mortality reported to poison centers across the United States from 2000 to 2014
Calcaterra SL et al.
Clin Toxicol

Twin epidemics: The surging rise of methamphetamine use in chronic opioid users
Ellis MS, Kasper ZA, Cicero TJ
Drug Alcohol Depend

Consistency between opioid-related mortality trends derived from poison center and National Vital Statistics System, United States, 2006-2016
Iwanicki JL et al.
Am J Public Health

Comparative rates of mortality and serious adverse effects among commonly prescribed opioid analgesics
Murphy DL, Lebin JA, Severtson SG, Olsen HA, Dasgupta N, Dart RC
Drug Saf

UK survey of non-medical use of prescription drugs (NMURx) as a valuable source of general population illicit drug use data
Ng FL, Rockhill K, Black J, May KP, Whittington MD, Wood DM, Dargan PI, Green JL
Postgrad Med J

Racial/ethnic differences in prevalence trends for heroin use and non-medical use of prescription opioids among entrants to Opioid Treatment Programs, 2005-2016
Pouget ER, Fong C, Rosenblum A
Subst Use Misuse

Prevention not Cure: Avoiding a European Prescription Opioid Epidemic
Smith DC, Dart RC, Hirst C
ONdrugDelivery

Assessment of tapentadol API abuse liability with the Researched Abuse, Diversion and Addiction-Related Surveillance (RADARS) System
Vosburg SK et al.
J Pain

Unit-dose packaging and unintentional buprenorphine-naloxone exposures
Wang GS, Severtson SG, Bau GE, Dart RC, Green, JL
Peds

Changes in misuse and abuse of prescription opioids following implementation of Extended-Release and Long-Acting Opioid Analgesic Risk Evaluation and Mitigation Strategy
Bucher Bartelson B et al.
Pharmacoepidemiol Drug Saf

Law enforcement-derived data on gabapentin diversion and misuse, 2002-2015: diversion rates and qualitative research findings
Buttram et al.
Pharmacoepidemiol Drug Saf

Understanding the demand side of the prescription opioid epidemic: does the initial source of opioids matter?
Cicero TJ, Ellis MS
Drug Alcohol Depend

Increased use of heroin as an initiating opioid of abuse
Cicero TJ, Ellis MS, Kasper ZA
Addict Behav

Increases in self-reported fentanyl use among a population entering drug treatment: the need for systematic surveillance of illicitly manufactured opioids
Cicero TJ, Ellis MS, Kasper ZA
Drug Alcohol Depend

Psychoactive substance use prior to the development of iatrogenic opioid abuse: A descriptive analysis of treatment-seeking opioid abusers
Cicero TJ, Ellis MS, Kasper ZA
Addict Behav

Relative preferences in the abuse of immediate-release versus extended-release opioids in a sample of treatment-seeking opioid abusers
Cicero TJ, Ellis MS, Kasper ZA
Pharmacoepidemiol Drug Saf

Do abuse deterrent opioids work?
Dart RC, Iwanicki JL, Dasgupta N, Cicero TJ, Schnoll SH
J Opioid Manag

Patterns of prescription drug use and misuse in Spain: The European Opioid Treatment Patient Survey
Fonseca F et al.
Heroin Addict Relat Clin Probl

Medical outcomes associated with prescription opioid abuse via oral and non-oral routes of administration
Green et al.
Drug Alcohol Depend

Changes in drug use patterns reported on the web after the introduction of ADF OxyContin: findings from the RADARS System Web Monitoring Program
Vosburg et al.
Pharmacoepidemiol Drug Saf

Assessment of tapentadol API abuse liability with the RADARS System
Vosburg SK, Severtson SG, Dart RC, Cicero TJ, Kurtz SP, Parrino MW, Green, JL
J Pain

A tale of 2 ADFs: differences in the effectiveness of abuse-deterrent formulations of oxymorphone and oxycodone extended-release drugs
Cicero TJ, Ellis MS, Kasper ZA
Pain

The prescription paradox of acetaminophen safety
Dart RC, Green JL
Pharmacoepidemiol Drug Saf

Diversion and illicit sale of extended release tapentadol in the United States
Dart RC, Surratt HL, Le Lait MC, Stivers Y, Bebarta VS, Freifeld CC, Brownstein JS, Burke JJ, Kurtz SP, Dasgupta N
Pain Med

Abuse and diversion of immediate release opioid analgesics as compared to extended release formulations in the United States
Iwanicki JL et al.
PLoS ONE

Opioid misuse in the 30 days prior to entering Agonist Opioid Treatment in four European Countries. A pilot study
Maremmani I et al.
Heroin Addict Relat Clin Probl

Sustained reduction of diversion and abuse after introduction of an abuse deterrent formulation of extended release oxycodone
Severtson SG et al.
Drug Alcohol Depend

Prescription opioid exposures and adverse outcomes among older adults
West NA, Dart RC
Pharmacoepidemiol Drug Saf

Analysis of the abuse and diversion of the buprenorphine transdermal delivery system
Wiegand TJ, Le Lait MC, Bucher Bartelson B, Dart RC, Green JL
J Pain

Abuse-deterrent formulations and the prescription opioid abuse epidemic in the United States: lessons learned from OxyContin
Cicero TJ, Ellis MS
JAMA Psychiatry

Abuse-deterrent formulations of prescription opioids [Letter to the Editor]
Cicero TJ, Ellis MS
JAMA Psychiatry

Shifting patterns of prescription opioid and heroin abuse in the United States [Letter to the Editor]
Cicero TJ, Ellis MS, Harney J
N Engl J Med

Trends in opioid analgesic abuse and mortality in the United States
Dart RC, Surratt HL, Cicero TJ, Parrino MW, Severtson SG, Bucher Bartelson B, Green JL
N Engl J Med

Abuse-deterrent formulations of prescription opioids [Letter to the Editor]
Dart RC, Severtson SG, Green JL
JAMA Psychiatry

Characteristics of non-opioid substance misusers among patients enrolling in opioid treatment programs: a latent class analysis
Fong C, Matusow H, Cleland CM, Rosenblum A
Journal of Addictive Diseases

Prescription opioids (substitution medications and pain medication) in patients looking for Opioid Agonist Treatment in Northern and Southern Italy, using a 18-month survey methodology
Maremmani I et al.
Heroin Addict Relat Clin Probl

Trends in abuse and misuse of prescription opioids among older adults
West NA, Severtson SG, Green JL, Dart RC
Drug Alcohol Depend

The changing face of heroin use in the United States: a retrospective analysis of the past 50 years
Cicero TJ, Ellis MS, Surratt HL, Kurtz SP
JAMA Psychiatry

Factors contributing to the rise of buprenorphine misuse: 2008-2013
Cicero TJ, Ellis MS, Surratt HL, Kurtz SP
Drug Alcohol Depend

Non-medical use of tapentadol immediate release by college students
Dart RC, Bucher Bartelson B, Adams EH
Clinical Journal of Pain

Seasonal variation in suicidal behavior with prescription opioid medicine
Davis JM, Searles VB, Severtson G, Dart RC, Bucher-Bartelson B
Journal of Affective Disorders

Using poison center exposure calls to predict prescription opioid abuse and misuse-related emergency department visits
Davis JM, Severtson SG, Bucher-Bartelson B, Dart RC
Pharmacoepidemiol Drug Saf

Abuse and diversion of buprenorphine sublingual tablets and film
Lavonas EJ et al.
Journal of Substance Abuse Treatment

Assessment of prescription opioid intentional exposures across the rural-urban continuum in the United States using both population and drug availability rates
Le Lait MC et al.
Pharmacoepidemiol Drug Saf

Tamper-resistant opioid formulations in the treatment of acute pain
Passik SD
Advances in Therapy

Reductions in prescription opioid diversion following recent legislative interventions in Florida
Surratt HL, O'Grady C, Kurtz SP, Stivers Y, Cicero TJ, Dart RC, Chen M
Pharmacoepidemiol Drug Saf